ITGB3, integrin subunit beta 3, 3690

N. diseases: 260; N. variants: 44
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.590 GeneticVariation group LHGDN Association of human platelet alloantigen 1 through 5 polymorphisms with ischemic stroke. 18057877 2008
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.590 GeneticVariation group LHGDN Previous studies showed an association between the GPIIIa Pl(A1/A2) polymorphism and coronary thrombosis, while there is only contrasting evidence about its role in stroke. 17278970 2007
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.590 GeneticVariation group LHGDN PLA1/A2 polymorphism of the platelet glycoprotein receptor IIb/IIIa in young patients with cryptogenic TIA or ischemic stroke. 12586134 2002
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.590 Biomarker group RGD Analysis of combined treatment of embolic stroke in rat with r-tPA and a GPIIb/IIIa inhibitor. 15678115 2005
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.590 GeneticVariation group BEFREE A common isoform of integrin β3, Leu33Pro is associated with enhanced platelet function and increased risk for coronary thrombosis and stroke, although these findings remain controversial. 24695082 2014
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.590 GeneticVariation group BEFREE We used a population-based case-control design to examine the association of the GpIIIa polymorphism P1A2 with stroke in young women. 9506596 1998
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.590 GeneticVariation group BEFREE Previous studies showed an association between the GPIIIa Pl(A1/A2) polymorphism and coronary thrombosis, while there is only contrasting evidence about its role in stroke. 17278970 2007
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.590 GeneticVariation group LHGDN In contrast to females with LVD stroke, we found that males with LVD stroke presented with an overrepresentation of at least 1 A2 allele of the GpIIIa gene when compared with their controls (39.7% versus 23.0%; P=0.003). 15178823 2004
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.590 GeneticVariation group BEFREE We investigated the association of the GpIIb/IIIa complex gene polymorphism with stroke risk in 306 patients with acute ischemic stroke and 266 control subjects by determining the GpIIb and GpIIIa genotype from leukocyte DNA by polymerase chain reaction (PCR) followed by FokI and ScrFI digestion, respectively. 22207115 2012
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.590 GeneticVariation group BEFREE We then assessed the relation of allelic variants of genes modulating clopidogrel absorption (ABCB1), metabolic activation (CYP3A5 and CYP2C19), and biologic activity (P2RY12 and ITGB3) to the risk of death from any cause, nonfatal stroke, or myocardial infarction during 1 year of follow-up. 19106083 2009
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.590 GeneticVariation group BEFREE The genotype distribution of the GpIIIa gene in patients with LVD stroke (A1/A1, 63%; A1/A2, 34.8%; A2/A2, 2.2%) differed significantly from their controls (A1A1, 79.3%; A1/A2, 20.1%; A2/A2, 0.6%). 15178823 2004
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.590 Biomarker group BEFREE Positive associations between total number of pMVs, AnV+ MVs and AnV+/CD61+ MVs and atherosclerotic thickening of carotid intima-media in stroke patients were found. 30763823 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.590 Biomarker group CTD_human Depressed platelet status in an elderly patient with hemorrhagic stroke after thrombolysis for acute myocardial infarction. GUSTO-III Investigators. 9445356 1998
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.360 Biomarker group LHGDN Inhibition of alpha(v)beta3 integrin reduces angiogenesis, bone turnover, and tumor cell proliferation in experimental prostate cancer bone metastases. 14524530 2003
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.360 Biomarker group LHGDN Osteoblasts-derived BMP-2 enhances the motility of prostate cancer cells via activation of integrins. 18512729 2008
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.360 AlteredExpression group LHGDN Expression and activation of alpha v beta 3 integrins by SDF-1/CXC12 increases the aggressiveness of prostate cancer cells. 17034033 2007
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.360 AlteredExpression group LHGDN Alpha(v)beta3 integrin expression up-regulates cdc2, which modulates cell migration. 12771130 2003
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.360 Biomarker group CTD_human [Prognostic implications of GP3a glucoprotein gene PLA1/PLA2 allele in prostatic cancer: pilot results of the study]. 16158739 2005
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.360 AlteredExpression group LHGDN Role of the orphan nuclear receptor ROR alpha in the control of the metastatic behavior of androgen-independent prostate cancer cells. 12168086 2003
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.360 AlteredExpression group LHGDN Prostate cancer specific integrin alphavbeta3 modulates bone metastatic growth and tissue remodeling. 17369840 2007
CUI: C0003838
Disease: Arterial Occlusive Diseases
Arterial Occlusive Diseases
0.200 Biomarker group RGD Inhibition of the intimal hyperplasia in an arterial autograft model by blockade of the N-terminal of the integrin beta3 subunit by monoclonal antibody P37. 16793666 1997
CUI: C0004626
Disease: Pneumonia, Bacterial
Pneumonia, Bacterial
0.200 Biomarker group RGD Expression of integrin subunits alphav and beta3 in acute lung inflammation. 15114484 2004
CUI: C0477317
Disease: Other primary thrombocytopenia
Other primary thrombocytopenia
0.200 Biomarker group MGD Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival. 9916135 1999
CUI: C0477317
Disease: Other primary thrombocytopenia
Other primary thrombocytopenia
0.200 Biomarker group MGD Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins. 11786903 2002
CUI: C0477317
Disease: Other primary thrombocytopenia
Other primary thrombocytopenia
0.200 Biomarker group MGD Beta3 integrin deficiency promotes cardiac hypertrophy and inflammation. 17184791 2007